The game kicks off at 4.45pm, with coverage on BBC One starting from 4pm, with live commentary also on BBC Radio 5 Live.
This weekend's 6 nations action concludes this afternoon as England take on Scotland at Murrayfield.
The 124th Calcutta Cup is one of the most eagerly anticipated match-ups of recent years as both teams look to build on strong starts in this year's tournament.
England head north of the border following wins over Italy and Wales in both of their opening matches, and will now be looking to make it three in a row. The fit-again Nathan Hughes replaces Sam Simmonds at number eight in the only change for Eddie Jones' side, with Joe Marler returning to the bench after serving his suspension.
Scotland will be looking to build on their morale-boosting win over France in their last game with a victory over the Auld Enemy at their home stadium, a feat they have not achieved since 2008.
Fans will be encouraged by an unchanged team from that which started the victory two weeks ago, with WP Nel returning to the bench in Scotland's only change.
If you've not managed to get tickets for the big game, and can't get to a TV, here is TechRadar's guide to watching all the Six Nations action online, wherever you are in the world.
1. How to watch England v Scotland 6 nations rugby online
This is the best way to watch England v Scotland 6 nations online - from absolutely anywhere in the world - without any commercial breaks:
Where can I watch the 6 nations rugby using a VPN?
A VPN will enable you to watch the 6 nations rugby from literally anywhere. So that obviously includes: US, UK, Israel, Belgium, Canada, Germany, Denmark, India, Netherlands, Spain, Brazil, Belgium, Romania, Mexico, France, Sweden, Italy, Portugal, Czech Republic, Ireland, Poland, Kenya, Hungary, South Africa, Indonesia, China, Nigeria, Bangladesh, Russia, Japan, Egypt and more!
2. How to watch the 6 nations rugby in the UK in its entirety:
If you’re in the UK and if you have a TV licence, then BBC iPlayer is where you should go for the 6 nations as the official broadcaster for the tournament; you may be asked to register for free in order to watch it though but it is a doddle and once you do it, you can enjoy it almost anywhere.: on your mobile, your media player, tablet, your web browser, streaming device, gaming console, TV, cable and satellite operators etc.
3. How to watch England v Scotland 6 nations rugby in the US in its entirety:
As mentioned above, if you're not based in the UK and want to watch the 6 nations rugby live, you won't be able to access the BBC live coverage without using a VPN.
In the US, NBC’s Sports Gold subscription streaming service will be showing all of 2018 6 nations tournament live. The channel's Rugby Pass costs $59.99, but also includes a whole heap of other rugby action, including Premiership Rugby and the 7s World Cup.
Stay safe during the 6 nations rugby
Photos courtesy of SixNationsRugby.com
